Dmd058586 1914..1920
نویسندگان
چکیده
Antibody-drug conjugates (ADCs) are a class of therapeutics that are designed to deliver potent small-molecule drugs selectively to cells that express a specific target antigen while limiting systemic exposure to the drug. This is accomplished by conjugating a potent drug onto an antibody-based therapeutic with a linker that is exquisitely stable in plasma. The development of an effective ADC requires optimizing a number of design elements and an extensive understanding of absorption, distribution, metabolism/catabolism, and elimination (ADME) processes for the ADC construct. Furthermore, as ADCs are a combination of an antibody and smallmolecule drug, understanding key aspects of the ADME of each individual component is needed. This review aims to provide considerations for the development of ADCs from an ADME point
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Determination of the Acetone Bodies in Blood.*
Comparatively few methods are available for the determination of the acetone bodies in blood. Marriott (1913-14, b) has described a method by which the nephelometric technique described by him (1913-14, a) could be applied to the determination of these substances in blood. Scott-Wilson’s reagent was used in this determination (Scott-Wilson, 1911). Marriott used this method in studying the relat...
متن کاملDetermination of the Acetone Bodies in Blood.*
Comparatively few methods are available for the determination of the acetone bodies in blood. Marriott (1913-14, b) has described a method by which the nephelometric technique described by him (1913-14, a) could be applied to the determination of these substances in blood. Scott-Wilson’s reagent was used in this determination (Scott-Wilson, 1911). Marriott used this method in studying the relat...
متن کاملReview of the genus Craspedolcus Enderlein sensu lato in China, with the description of a new genus and four new species (Hymenoptera, Braconidae, Braconinae)
A new genus is split off the genus Craspedolcus Enderlein, 1920 (Hymenoptera, Braconidae, Braconinae): Maculibracongen. n. with type species Maculibracon abruptussp. n. The genus Craspedolcus Enderlein sensu stricto is redefined, a key to both genera and to their species in China, Thailand and Vietnam is included. Craspedolcus obscuriventris Enderlein, 1920, (syn. n.) is a new synonym of Craspe...
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The first comprehensive town planning legislation in Australia was enacted by the Western Australian Parliament in 1929. This followed a number of events in Australia to showcase the benefits of town planning, from 1914, onwards. They included an Australasian town planning tour by Charles Reade on behalf of the Garden Cities and Town Planning Association of Great Britain, in 1914 -1915, after w...
متن کاملThe Daily Rhythm of Activity of the Cockroach, Blatta Orientalis L. I. Aktograph Experiments, Especially in Relation to Light
IN the last few years there has been an increasing interest in animal rhythms. Various aspects of the subject have been reviewed by Szymanski (1920), Fox (1923), Hoffmann (1926), Richter (1927), AmirthaUngam (1928), Stein-Beling (1935), Scott (1936), Gunn et al. (1937), Pie'ron (1937) and Kalmus (1938a, b). This paper is concerned with the daily rhythm in the locomotory activity of the cockroac...
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